Division of Biostatistics and Bioinformatics, Department of Oncology
Johns Hopkins Medicine, Sidney Kimmel Comprehensive Cancer Center
Department of Biostatistics
Johns Hopkins Bloomberg School of Public Health
Cancer Etiology, Evolution, Early Detection and Risk Prediction Mathematical Modeling – Biostatistics
Two factors are widely recognized as causing cancer: environment (E) and heredity (H).
A paper published in Science in 2015 provided evidence for a third factor: the random mistakes made when normal stem cells divide. The results in this paper showed that there was a strong correlation between the lifetime number of normal stem cell divisions in an organ and its lifetime cancer incidence. This contributes to explain why certain cancer types have a much higher incidence than others….