• CANCER ETIOLOGY, EVOLUTION, EARLY DETECTION AND RISK PREDICTION

    Mathematical Modeling - Machine Learning - Biostatistics

  • Bad Luck Theory

    Cristian Tomasetti & Bert Vogelstein explain the Bad Luck Theory

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  • Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence

    PNAS

    We have discovered a species-specific feature of the aging process: significantly slowed division rates in self-renewing tissues of humans. In contrast, we found only small to no decrease in division rates in self-renewing tissues of mice, for whom cancer incidence does not decelerate with age.

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ASSOCIATE PROFESSOR

Division of Biostatistics and Bioinformatics, Department of Oncology

Johns Hopkins Medicine, Sidney Kimmel Comprehensive Cancer Center

Department of Biostatistics

Johns Hopkins Bloomberg School of Public Health

Cancer Etiology, Evolution, Early Detection and Risk Prediction Mathematical Modeling – Biostatistics

Two factors are widely recognized as causing cancer: environment (E) and heredity (H).

A paper published in Science in 2015 provided evidence for a third factor: the random mistakes made when normal stem cells divide. The results in this paper showed that there was a strong correlation between the lifetime number of normal stem cell divisions in an organ and its lifetime cancer incidence. This contributes to explain why certain cancer types have a much higher incidence than others….