2019


#36

Lahouel K, Younes L, Danilova L, Giardiello FM, Hruban RH, Groopman J, Kinzler KW, Vogelstein B, Geman D, Tomasetti C*. Revisiting the tumorigenesis timeline with a data-driven generative model. Proc Natl Acad Sci USA, in press.


#35

Tomasetti C*, Poling J, Roberts NJ, London Jr. NR, Pittman ME, Haffner MC, Rizzo A, Baras A, Karim B, Kim A, Heaphy CM, Meeker AK, Hruban RH, Iacobuzio- Donahue CA, Vogelstein B. Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence. Proc Natl Acad Sci USA 2019,


#34

Tie J, Cohen J, Wang Y, Li L, Christie M, Simons K, Lee M, Wong R, Kosmider S, Ananda S, McKendrick J, Lee B, Cho JH, Faragher I, Jones I, Tomasetti C, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer. JAMA Oncology, doi:https://doi.org/10.1001/jamaoncol.2019.3616.


#33

Tomasetti C*. Mutated clones are the new normal. Science 2019, 364(6444):938-939.


#32

Springer S, Masica DL, Dal Molin M, Douville C, Thoburn C, Afsari B, Li L, Cohen J, Thompson E, Allen PJ, Klimstra DS, Schattner MA, Schmidt CM, Yip-Schneider M, Simpson R, Fernandez-Del Castillo C, Mino-Kenudson M, Brugge W, Brand RE, Singhi AD, Scarpa A, Lawlor R, Salvia R, Zamboni G, Hong S-M, Hwang DW, Jang J-Y, Kwon W, Swan N, Geoghegan J, Falconi M, Crippa S, Doglioni C, Paulino J, Schulick R, Edil BH, Park W, Yachida S, Hijioka S, van Hooft J, He J, Weiss MJ, Burkhart R, Makary M, Canto MI, Goggins MG, anine Ptak J, Dobbyn L, Schaefer J, Sillman N, Popoli M, Klein A, Tomasetti C*, Karchin R, Papadopoulos N, Kinzler KW, Vogelstein B, Wolfgang CL, Hruban RH, Lennon AM. A multimodality test to guide the management of patients with a pancreatic cyst. Sci Transl Med 2019, 11(501): eaav4772.


#31

Lee B, Lipton L, Cohen J, Tie J, Ammar Javed A, Li L, Goldstein D, Burge M, Cooray P, Nagrial A, Tebbutt N, Thomson B, Nikfarjam M, Harris M, Haydon A, Lawrence B, Tai D, Lennon AM, Wolfgang C, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P. Circulating tumor DNA as a potential marker of adjuvant chemotherapy benefit following surgery for localised pancreatic cancer. Ann Oncol 2019, 30(9):1472-1478.


#30

Wang Y, Li L, Cohen J, Kinde I, Ptak J, Popoli M, Schaefer J, Silliman N, Dobbyn L, Tie J, Gibbs P, Tomasetti C, Kinzler KW, Papadopoulos N, Vogelstein B, Olsson L. Prognostic potential of circulating tumor DNA measurement in post-operative surveillance of non-metastatic colorectal cancer. JAMA Oncology 2019, doi:10.1001/jamaoncol.2019.0512.


#29

Wu R-C, Wang P, Lin S-F, Zhang M, Song Q, Chu T, Wang BG, Kurman RJ, Vang R, Kinzler K, Tomasetti C*, Jiao Y, Shih I-M, Wang T-L. Genomic landscape and evolutionary trajectories of ovarian cancer precursor lesions. J Pathol 2019, doi:10.1002/path.5219.


#28

Eich M-L, Pena M, Springer S, Taheri D, Tregnago A, Salles D, Bezerra S, Cunha I, Fujita K, Ertoy D, Bivalacqua T, Tomasetti C, Papadopoulos N, Kinzler K, Vogelstein B, Netto G. Incidence and distribution of UroSEEK gene panel in a multi-institutional cohort of bladder urothelial carcinoma. Modern Pathology 2019, doi:10.1038/s41379-019-0276-y.


#27

Wong R, Tie J, Lee M, Cohen JD, Wang Y, Li L, Ma S, Christie M, Kosmider S, Tomasetti C, Papadopoulos N, Kinzler K, Vogelstein B, Gibbs P. The potential role of circulating tumor DNA (ctDNA) in the further investigation of colorectal cancer patients with nonspecific findings on standard investigations. Int J Cancer 2019, doi:10.1002/ijc.32117.


#26

Song M, Vogelstein B, Giovannucci EL, Willett WC, Tomasetti C. Cancer prevention: Molecular and epidemiological consensus. Science 2018, 361(6409):1317-1318.


#25

Wang Y, Li L, Douville C, Cohen JD, Yen T-T, Kinde I, Sundfelt K, Kjær SK, Hruban RH, Shih I-M, Wang T-L, Kurman RJ, Springer S, Ptak J, Popoli M, Schaefer J, Silliman N, Dobbyn L, Tanner EJ, Angarita A, Lycke M, Jochumsen K, Afsari B, Danilova L, Levine DA, Jardon K, Zeng X, Arseneau J, Fu L, Diaz LA, Karchin R, Tomasetti C*, Kinzler KW, Vogelstein B, Fader AN, Gilbert L, Papadopoulos N. Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancersSci Transl Med 2018, 10(433): eaap8793.


#24

Springer SU, Chen C-H, Pena MCR, Li L, Douville C, Wang Y, Cohen JD, Taheri D, Silliman N, Schaefer J, Ptak J, Dobbyn L, Popoli M, Kinde I, Afsari B, Tregnago AC, Bezerra SM, VandenBussche C, Fujita K, Ertoy D, Cunha IW, Yu L, Bivalacqua TJ, Grollman AP, Diaz LA, Karchin R, Danilova L, Huang C-Y, Shun C-T, Turesky RJ, Yun BH, Rosenquist TA, Pu Y-S, Hruban RH, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Dickman KG, Netto GJ. Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy. eLIFE 2018, 7:e32143.


#23

Tie J, Cohen JD, Wang Y, Li L, Christie M, Simons K, Elsaleh H, Kosmider S, Wong R, Yip D, Lee M, Tran B, Rangiah D, Burge M, Goldstein D, Singh M, Skinner I, Faragher I, Croxford M, Bampton C, Haydon A, Jones IT, Karapetis CS, Price T, Schaefer MJ, Ptak J, Dobbyn L, Silliman N, Kinde I, Tomasetti C, Papadopoulos N, Kinzler K, Bert Volgestein B, Gibbs P. Serial circulating tumour DNA analysis during multimodality treatment of locally advanced rectal cancer: a prospective biomarker study. Gut 2019, 68 (4):663-671.

2018


#22

Cohen JD, Li L, Wang Y, Thorburn C, Afsari B, Danilova L, Douville C, Javed AA, Wong F, Mattox A, Hruban RH, Wolfgang CL, Goggins MG, Dal Molin M, Wang T-L, Roden R, Klein AP, Ptak J, Dobbyn L, Schaefer J, Silliman N, Popoli M, Vogelstein JT, Browne JD, Schoen RE, Brand RE, Tie J, Gibbs P, Wong H-L, Mansfield AS, Jen J, Hanash SM, Falconi M, Allen PJ, Zhou S, Bettegowda C, Diaz L, Tomasetti C*, Kinzler KW, Vogelstein B, Lennon AM, Papadopoulos N. Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 2018, 359(6378):926-930.


#21

Cohen JD, Javed AA, Thoburn C, Wong F, Tie J, Gibbs P,Schmidt CM, Yip-Schneider M, Allen PJ, Schattner M, Brand RE, Singhi AD, Petersen GM, Hong S-M, Kim S, Falconi M, Doglioni C, Weiss MJ, Ahuja N, He J, Makary M, Maitra A, Hanash SM, Dal Molin M, Wang Y, Li L, Ptak J, Dobbyn L, Schaefer J, Silliman N, Popoli M, Goggins M, Hruban RH, Wolfgang CL, Klein AP, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Lennon AM. Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. Proc Natl Acad Sci USA 2017, 114(38):10202-10207.


#20

Tomasetti C*, Durrett R, Kimmel M, Lambert A, Parmigiani G, Zauber A, Vogelstein B. Role of stem cell divisions in cancer risk. Nature 2017, 548: E13-E14, doi:10.1038/nature23302.


#19

Tomasetti C*, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science 2017, 355(6331):1330-1334.


#18

Anglesio MS, Papadopoulos N, Ayhan A, Nazeran TM, Horlings HM, Noe M, Lum A, Jones S, Senz J, Seckin T, Ho J, Wu R-C, Lac V, Ogawa H, Tessier-Cloutier B, Alhassan R, Wang A, Wang Y, Cohen J, Wong F, Hasanovic A, Orr N, Wang M, Popoli M, McMahon W, Wood L, Mattox A, Allaire C, Segars J, Williams C, Tomasetti C, Boyd N, Kinzler KW, Gilks CB, Diaz L, Wang T-L, Vogelstein B, Yong PJ, Huntsman DG, Shih I-M. Cancer associated mutations in non-cancer associated endometriosis. N Engl J Med 2017, 376(19):1835-1848.


#17

Tomasetti C*, Vogelstein B.  On the slope of the regression between stem cell divisions and cancer risk, and the lack of correlation between stem cell divisions and environmental factors-associated cancer risk.  PLoS ONE 2017, 12(5):e0175535.

2017


#16

Tie J, Wang Y, Tomasetti CLi L, Springer S, Kinde I, Silliman N, Tacey M, Wong H, Christie M, Kosmider S, Skinner I, Wong R, Steel M, Tran B, Desai J, Jones I, Haydon A, Hayes T, Price TJ, Strausberg RL, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P.  Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer.  Sci Transl Med 2016, 8(346):346ra92.


#15

Hoang ML, Kinde I, Tomasetti C, McMahon KW, Rosenquist TA, Grollman AP, Kinzler KW, Vogelstein B, Papadopoulos N.  Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing.  Proc Natl Acad Sci USA 2016, 113(35):9846-9851.

2015


#14

Tomasetti C*, Vogelstein B.  Cancer risk: role of environment – Response.  Science 2015, 347(6223):729-731.


#13

Tomasetti C*, Vogelstein B.  Variation in cancer risk among tissues can be explained by the number of stem cell divisions.  Science 2015, 347(6217):78-81.


#12

Tomasetti C*, Marchionni L, Nowak MA, Parmigiani G, Vogelstein B.  Only three driver gene mutations are required for the development of lung and colorectal cancer.  Proc Natl Acad Sci USA 2015, 112(1):118-123.


#11

Tomasetti C*, Bozic I.  The (not-so) immortal strand hypothesis.  Stem Cell Research 2015, 14(2):238-241.

2014


#10

Geman D, Ochs M, Price ND, Tomasetti C, Younes L.  An argument for mechanism-based statistical inference in cancer.  Human Genetics 2014, DOI:10.1007/s00439-014-1501-x.

2013


#9

Tomasetti C*, Demetri GD, Parmigiani G.  Why tyrosine kinase inhibitor resistance is common in advanced gastrointestinal stromal tumors.  F1000 Research 2013, 2:152.


#8

Tomasetti C*, Vogelstein B, Parmigiani G.  Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation.  Proc Natl Acad Sci USA 2013, 110(6):1999-2004.

2012


#7

Tomasetti C*Stochastic modeling of multiple random genetic mutations under the cancer stem cell hypothesis.  Mathematical Population Studies 2012, 19(4):200-213.


#6

Tomasetti C*On the probability of random genetic mutations for various types of tumor growth.  Bulletin of Mathematical Biology 2012, 74(6):1379-1395.

2011


#5

Tomasetti C*A new hypothesis: imatinib affects leukemic stem cells in the same way it affects all other leukemic cells.  Blood Cancer Journal 2011, 1:e19.

2010


#4

Tomasetti C*, Levy D.  Role of symmetric and asymmetric division of stem cells in developing drug resistance.  Proc Natl Acad Sci USA 2010, 107(39):16766-16771.


#3

Galante A, Levy D, Tomasetti C*A mathematical model for microenvironmental control of tumor growth.  IFMBE Proceedings 2010, in K.E. Herold, W.E. Bentley, and J. Vossoughi (Eds.): SBEC 2010, IFMBE Proceedings 32, Springer, 2010, pp. 213-216.


#2

Tomasetti C*, Levy D.  Drug resistance always depends on the cancer turnover rate.  IFMBE Proceedings 2010, in K.E. Herold, W.E. Bentley, and J. Vossoughi (Eds.): SBEC 2010, IFMBE Proceedings 32, Springer, 2010, pp. 552-555.


#1

Tomasetti C*, Levy D.  An elementary approach to modeling drug resistance in cancer.  Math Biosci Eng 2010, 7(4):905-918.


(* if corresponding author; members of my lab in blue)