Publications

#212017

Cohen JD, Javed AA, Thoburn C, Wong F, Tie J, Gibbs P,Schmidt CM, Yip-Schneider M, Allen PJ, Schattner M, Brand RE, Singhi AD, Petersen GM, Hong S-M, Kim S, Falconi M, Doglioni C, Weiss MJ, Ahuja N, He J, Makary M, Maitra A, Hanash SM, Dal Molin M, Wang Y, Li L, Ptak J, Dobbyn L, Schaefer J, Silliman N, Popoli M, Goggins M, Hruban RH, Wolfgang CL, Klein AP, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Lennon AM. Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers. Proc Natl Acad Sci USA 2017, published ahead of print September 5, 2017, doi:10.1073/pnas.1704961114

#202017

Tomasetti C*, Durrett R, Kimmel M, Lambert A, Parmigiani G, Zauber A, Vogelstein B. Role of stem cell divisions in cancer risk. Nature 2017, 548: E13-E14, doi:10.1038/nature23302.

#192017

Tomasetti C*, Li L, Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science 2017, 355(6331):1330-1334.

#182017

Anglesio MS, Papadopoulos N, Ayhan A, Nazeran TM, Horlings HM, Noe M, Lum A, Jones S, Senz J, Seckin T, Ho J, Wu R-C, Lac V, Ogawa H, Tessier-Cloutier B, Alhassan R, Wang A, Wang Y, Cohen J, Wong F, Hasanovic A, Orr N, Wang M, Popoli M, McMahon W, Wood L, Mattox A, Allaire C, Segars J, Williams C, Tomasetti C, Boyd N, Kinzler KW, Gilks CB, Diaz L, Wang T-L, Vogelstein B, Yong PJ, Huntsman DG, Shih I-M. Cancer associated mutations in non-cancer associated endometriosis. N Engl J Med 2017, 376(19):1835-1848.

#172017

Tomasetti C*, Vogelstein B.  On the slope of the regression between stem cell divisions and cancer risk, and the lack of correlation between stem cell divisions and environmental factors-associated cancer risk.  PLoS ONE 2017, 12(5):e0175535.

#162016

Tie J, Wang Y, Tomasetti CLi L, Springer S, Kinde I, Silliman N, Tacey M, Wong H, Christie M, Kosmider S, Skinner I, Wong R, Steel M, Tran B, Desai J, Jones I, Haydon A, Hayes T, Price TJ, Strausberg RL, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P.  Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer.  Sci Transl Med 2016, 8(346):346ra92.

#152016

Hoang ML, Kinde I, Tomasetti C, McMahon KW, Rosenquist TA, Grollman AP, Kinzler KW, Vogelstein B, Papadopoulos N.  Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing.  Proc Natl Acad Sci USA 2016, 113(35):9846-9851.

#142015

Tomasetti C*, Vogelstein B.  Cancer risk: role of environment – Response.  Science 2015, 347(6223):729-731.

#132015

Tomasetti C*, Vogelstein B.  Variation in cancer risk among tissues can be explained by the number of stem cell divisions.  Science 2015, 347(6217):78-81.

#122015

Tomasetti C*, Marchionni L, Nowak MA, Parmigiani G, Vogelstein B.  Only three driver gene mutations are required for the development of lung and colorectal cancer.  Proc Natl Acad Sci USA 2015, 112(1):118-123.

#112015

Tomasetti C*, Bozic I.  The (not-so) immortal strand hypothesis.  Stem Cell Research 2015, 14(2):238-241.

#102014

Geman D, Ochs M, Price ND, Tomasetti C, Younes L.  An argument for mechanism-based statistical inference in cancer.  Human Genetics 2014, DOI:10.1007/s00439-014-1501-x.

#92013

Tomasetti C*, Demetri GD, Parmigiani G.  Why tyrosine kinase inhibitor resistance is common in advanced gastrointestinal stromal tumors.  F1000Research 2013, 2:152.

#82013

Tomasetti C*, Vogelstein B, Parmigiani G.  Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation.  Proc Natl Acad Sci USA 2013, 110(6):1999-2004.

#72012

Tomasetti C*Stochastic modeling of multiple random genetic mutations under the cancer stem cell hypothesis.  Mathematical Population Studies 2012, 19(4):200-213.

#62012

Tomasetti C*On the probability of random genetic mutations for various types of tumor growth.  Bulletin of Mathematical Biology 2012, 74(6):1379-1395.

#52011

Tomasetti C*A new hypothesis: imatinib affects leukemic stem cells in the same way it affects all other leukemic cells.  Blood Cancer Journal 2011, 1:e19.

#42010

Tomasetti C*, Levy D.  Role of symmetric and asymmetric division of stem cells in developing drug resistance.  Proc Natl Acad Sci USA 2010, 107(39):16766-16771.

#32010

Galante A, Levy D, Tomasetti C*A mathematical model for microenvironmental control of tumor growth.  IFMBE Proceedings 2010, in K.E. Herold, W.E. Bentley, and J. Vossoughi (Eds.): SBEC 2010, IFMBE Proceedings 32, Springer, 2010, pp. 213-216.

#22010

Tomasetti C*, Levy D.  Drug resistance always depends on the cancer turnover rate.  IFMBE Proceedings 2010, in K.E. Herold, W.E. Bentley, and J. Vossoughi (Eds.): SBEC 2010, IFMBE Proceedings 32, Springer, 2010, pp. 552-555.

#12010

Tomasetti C*, Levy D.  An elementary approach to modeling drug resistance in cancer.  Math Biosci Eng 2010, 7(4):905-918.